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Laboratory's major interest is the understanding of molecular alterations underlying the presentation of different forms of cancer in young age as well as the familial segregation of specific types of cancer (e.g. breast, ovarian, colorectal, pancreatic, prostate).

The following forms of Hereditary Cancer are studied:


Hereditary Breast Ovarian Cancer type I, II & III (HBOCI, II, III, genes BRCA1, BRCA2, CHEK2)

see BRCA1 & BRCA2 mutation spectrum in Greece


Hereditary non-Polyposis Colorectal Cancer (HNPCC, genes MLH1, MSH2, MSH6, PMS2)

Familial Adenomatous Polyposis (FAP, gene APC)

MutYH Associated Polyposis (MAP, gene MutYH)

Multiple Endocrine Neoplasia Type I & II (MENI and MENII, genes MEN1, RET)

Hereditary Diffused Gastric Cancer (HDGC, gene CDH1)

Peutz-Jeghers Syndrome (PJS, gene STK11)

Cowden Syndrome (CS, gene PTEN)



Hereditary Cancer  BioBank

The bank includes:
1. 900 DNA samples from families with Hereditary Breast Ovarian Cancer and 3.000 sporadic breast cancer cases
2. 400 DNA samples from families with Colorectal and other Gastrointestinal  Cancers and 1.800 sporadic cases of colorectal cancer


Participation in International Consortia

•  COST program  Action BM0606 “Collaborative association studies in breast cancer” 9/2007-9/2011. Chair: Professor Peter Devilee, Leiden University.

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Evidence-based Network for Interpretation of Genome Modifying Alterations (ΕΝΙGMA). Coordinator: Professor David Goldgar & Dr Olga Sinilnikova, Utah University and International Association for Research in Cancer – Lyon, FR.

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Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Coordinator: Dr Georgia Chenevix-Trench, Queensland Institute of Medical Research, Brisbane, Australia.

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Genome Wide Association Study in triple negative breast cancers. Coordinator: Professor Fergus J. Couch, , Mayo Clinic, Rochester.

Collaborative Oncological Gene-environment Study – COGS. Coordinated by Prof. Per Hall, Karolinska Institute, Sweden

Leiden Open Variation Database. Coordinated by Prof. Hes FJ,  Departments of Clinical Genetics, Leiden University Medical Center,The Netherlands  






 
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